Medicine University in USA

Regenerative Medicine Generates Hope | BU

Gustavo Mostoslavsky, Darrell Kotton, George Murphy, founders Boston University Center for Regenerative Medicine, CReM, stem cell research

Scientific soul mates

Kotton, Mostoslavsky, and Murphy met as Harvard postdoctoral fellows in the lab of renowned stem cell scientist Richard Mulligan, who is famous for his rigorous research and forthright style of mentorship. “It was more of a sink-or-swim methodology, where you really had to prove yourself, ” says Murphy, a MED assistant professor of medicine. “Coming out of there, we were battle-tested and bombproof.”

The three gravitated toward each other as “scientific soul mates, ” Mostoslavsky says. Long after fellow researchers had left the lab, they would gather for late-night pizza and animated discussions, probing one another’s data to test the strength of their work. “We were each other’s worst critics as well as biggest fans, ” Kotton says. It was around that time that they began toying with the idea of conducting science their way—in a meticulous, yet open and collegial manner.

After completing his Harvard fellowship, in 2006 Kotton returned to MED, where he had done a fellowship previously, to launch his own lung stem cell lab. He confesses to “putting psychological pressure” on his friends to follow him to BU, and he is not at all unhappy that it worked. In 2008, Mostoslavsky came aboard, creating his own lab. He was followed soon after by Murphy.

Ryan Mulhern, Clarissa Koch, Bosotn University Center for Regenerative Medicine, CReMSeveral events conspired to launch CReM on the Medical Campus. The founders discovered a strong advocate in David Coleman, Wade Professor and chair of the MED department of medicine, who emphasized the importance of a robust research presence on the Medical Campus. Kotton, Mostoslavsky, and Murphy had followed closely the rapid advance of stem cell biology since 2006, when scientists at the University of Kyoto developed induced pluripotent stem cells (iPS) by reprogramming an adult differentiated cell. A tinkerer at heart, Mostoslavsky was fascinated by the Kyoto process, but felt he could go one better. In 2008, he developed a more efficient tool to generate stem cells, called the stem cell cassette (STEMCCA). BU patented the tool, which has become industry standard.

In 2010, with STEMCCA and multiple publications under their belts, the trio established a virtual Center for Regenerative Medicine, with its own website, seminar series, and iPS cell bank carrying branded labels. All this was accomplished while working in separate labs, with Murphy’s and Mostoslavsky’s divided by floors within a building, and Kotton’s located across the street.

As the number of stem cell biologists, physician-researchers, and biomedical engineers grew on both BU campuses, the affectionately labeled CReM brothers felt it was time to pitch a physical center to BU President Robert A. Brown, who firmly backed the idea. Boston University and Boston Medical Center invested jointly in the endeavor, and in November 2013, CReM opened in its newly remodeled space on the second floor of 670 Albany Street.

In the video above, CReM founders discuss how they use induced pluripotent stem (iPS) cells in their labs.

This is from the UCDavis Veterinary Medicine

by Catnipcomic1

Site, it's not up to date, but says only one place in the USA still does the test, it's since been discontinued.
Do you test for Feline Immunodeficiency Virus (FIV)?
As you may or may not be aware of, the Real-time PCR Research and Diagnostics Core Facility previously tested for FIV free of charge. While we could not charge for the test, we still ran it because we firmly believed it was an important diagnostic tool for differentiating between active infection and exposure/vaccine

Deaths in USA from lack of health care (someone

by Tommys

Asked yesterday)
USA today article...(18,000 a year)
infant mortality....african american rates closer to third world than any euro country...
"The U.S. ranking is driven partly by racial and income disparities. Among U.S. blacks, there are 9 deaths per 1,000 live births, closer to rates in developing nations than to those in the industrialized world...."
"... Black infants are twice as likely as white babies to be premature, to have a low birth weight and to die at birth, according to Save the Children

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